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1994-10-25
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Document 2913
DOCN M94A2913
TI Prognostic value of conventional EEG-recordings in evaluating
HIV-encephalopathy.
DT 9412
AU Arendt G; Bohn J; Schroerschwarz T; von Giesen HJ; Roick H; Jablonowski
H; Department of Neurology, Univ. Dusseldorf, FRG.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):196 (abstract no. PB0211). Unique
Identifier : AIDSLINE ICA10/94369662
AB OBJECTIVE: HIV-1-related dementia is said to be subcortical and
cortical. Whereas the subcortical form presents early in the course of
the disease with cognitive and motor signs, the cortical deficits are
not very well studied to date. METHODS: 109 neurologically asymptomatic
(no clinical, no markedly subclinical motor or cognitive deficits)
HIV-positive homosexuals (CDC II n = 29; CDC III n = 17; CDC IVA n = 4;
CDC IV C1 n = 16; CDC IV C2 n = 32; CDC IV D n = 11) underwent
conventional EEG-recordings according to the 10/20 system every six
months over an 18 months period. Alpha, beta, theta and delta
frequencies were spectralanalyzed. Results were correlated to the
clinical course and to CT and MRI scans. RESULTS: The most significant
EEG findings were a slowing of the alpha rhythm (< 9Hz) and a
pathological theta-index (> 10%) presenting in a higher percentage of
AIDS (19.1-54.0%) than non-AIDS (15.2-45.7%) patients. AIDS patients
with abnormal EEG-recordings revealed cortical atrophy in neuroimaging
whereas non-AIDS patients had normal scans. Non-AIDS patients revealed
no significant deterioration over time, but AIDS-patients showed a
continuous slowing of the alpha rhythm during the observation period.
Theta index abnormalities remained unchanged. In contrast to non-AIDS
individuals, 50% of the AIDS patients with initial EEG abnormalities
revealed signs of cortical dementia within the observation period,
nearly all of those showed also subcortical dementive signs. CONCLUSION:
EEG abnormalities--especially slowing of the alpha-rhythm--are of some
prognostic value for the development of cortical HIV-1-related
encephalopathy in AIDS, but not in non-AIDS patients.
DE Atrophy AIDS Dementia Complex/EPIDEMIOLOGY/*PHYSIOPATHOLOGY Cerebral
Cortex/PATHOLOGY *Electroencephalography Human Prognosis MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).